January 1, 1996Clinical and Experimental Hypertension
Experimental Approaches to Determining the Choice of First-Step Therapy for Patients with Hypertension
Why the study?
Does the choice of first-step antihypertensive therapy affect blood pressure outcomes and the incidence of fatal coronary heart disease and non-fatal myocardial infarction in patients with hypertension?
Population
Patients with hypertension
Comparison
First-step antihypertensive therapy vs Other classes of antihypertensive drugs
Design
Review
Authors
Discussion
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Implication
This review highlights ongoing large-scale trials, such as ALLHAT, designed to determine the optimal first-line antihypertensive therapy for preventing cardiovascular events.
Structured PICO
Does the choice of first-step antihypertensive therapy affect blood pressure outcomes and the incidence of fatal coronary heart disease and non-fatal myocardial infarction in patients with hypertension?
P
Population
Patients with hypertension
I
Intervention
First-step antihypertensive therapy (including newer classes such as calcium channel blockers, angiotensin converting enzyme inhibitors, and alpha 1 receptor blockers)
C
Comparator
Other classes of antihypertensive drugs (such as diuretics and beta-blockers)
O
Outcome
Blood pressure outcomes and combined incidence of fatal coronary heart disease and non-fatal myocardial infarctioncomposite
This review highlights ongoing large-scale trials, such as ALLHAT, designed to determine the optimal first-line antihypertensive therapy for preventing cardiovascular events.
Cite This Study
Whelton et al. (1996) studied this question.