Why the study?
Are blood vasoactive factors associated with blood pressure status in normotensive, prehypertensive, and hypertensive patients?
Observational
Are blood vasoactive factors associated with blood pressure status in normotensive, prehypertensive, and hypertensive patients?
Changes in blood vasoactive factors show a dose-response relationship with blood pressure status and may serve as early biomarkers for the progression to hypertension.
Should not alter hypertension management; leaves open whether vasoactive peptides predict progression or merit prospective study.
A pilot study was conducted to investigate blood pressure level and vasoactive factors (VFs) among age- and sex-matched normotensive (NT), prehypertensive (PH), and hypertensive (EH) subjects. The results showed that angiotensin, arginine vasopressin, and endothelin were significantly higher, while adrenomedullin and calcitonin gene-related peptide were lower in the EH group than in the PH and NT groups. Nitric oxide synthase was not different among the three groups. There was a dose-response relationship between VFs and BP status. The results suggested that changes in blood VFs might be early warning signs of the development of prehypertension to hypertension, and important biomarkers for the early prevention of prehypertension.
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Wang et al. (2008) conducted an observational in Prehypertension and Hypertension. Hypertension and prehypertension vs. Normotension was evaluated on Blood vasoactive factors.
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