Population
Kcnn4 null mice
Design
Preclinical
Authors
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Kcnn4 deletion impairs murine T-cell/erythrocyte volume regulation without affecting parotid secretion; hypothesis-generating for selective modulation, human relevance remains open.
Kcnn4 channels are required for volume regulation in red blood cells and T lymphocytes, but surprisingly play no required role in fluid secretion in the parotid gland.
Begenisich et al. (2004) studied this question.
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