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January 1, 2004Arthritis & Rheumatism

Angiotensin II in the lesional skin of systemic sclerosis patients contributes to tissue fibrosis via angiotensin II type 1 receptors

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Population

Patients with systemic sclerosis and healthy donors

Comparison

Exogenous Angiotensin II (in vitro) vs Normal subjects/fibroblasts; untreated cells

Design

Preclinical

Authors

YKYasushi KawaguchiKTKae TakagiMHMasako Hara

Discussion

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Overview

Hypothesis-generating for AT1 antagonism in SSc fibrosis; human trials needed before any clinical consideration.

Structured PICO

P
Population
Patients with systemic sclerosis (diffuse and limited cutaneous) and healthy donors (sera, skin samples, and cultured dermal fibroblasts)
I
Intervention
Exogenous Angiotensin II (in vitro)
C
Comparator
Normal subjects/fibroblasts; untreated cells
O
Outcome
Expression of Angiotensin II, angiotensinogen, AT1, and AT2 receptors, and production of type I procollagen and TGF-beta1surrogate

Aberrant Angiotensin II production and AT1 receptor activation contribute to tissue fibrosis in systemic sclerosis, suggesting AT1 receptor antagonists as a potential therapeutic strategy.

Cite This Study

Kawaguchi et al. (2004) studied this question.

synapsesocial.com/papers/6a79fcc574c579e25f89169ahttps://doi.org/10.1002/art.11364
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Modulation of angiotensin II signaling in the prevention of fibrosis2015 · 164 citations
  2. 2ACKR1+ Endothelial Cells Mediate Leukocyte Infiltration and Synergize with SFRP2/ASPN+ Fibroblasts to Promote Skin Fibrosis in Systemic Sclerosis2024 · 20 citations
  3. 3Angiotensin II Has Multiple Profibrotic Effects in Human Cardiac Fibroblasts2000 · 314 citations
  4. 4Induction of cardiac fibrosis by angiotensin II2000 · 84 citations
  5. 5Angiotensin II Stimulates Collagen Synthesis in Human Vascular Smooth Muscle Cells1999 · 116 citations