Population
Washed, prelabeled rabbit platelets pretreated with aspirin
Comparison
Ethanol combined with adenosine vs Ethanol alone, adenosine alone, or baseline
Design
Preclinical
Authors
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No immediate clinical implications; leaves open whether adenosine potentiates ethanol's antithrombotic effects in vivo.
Ethanol and adenosine exhibit combined inhibitory effects on thrombin-stimulated platelet responses in vitro, potentially explaining the pronounced antithrombotic effects of ethanol observed in vivo.
Rand et al. (1995) studied this question.