What is the clinical evidence from this study?

Study design: Other. Intervention: Ethanol. Primary outcome: Blood platelet aggregation.

June 5, 2008Pharmacology

Influence of Ethanol and Serotonin on Rat Platelet Aggregation

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Key result

Ethanol significantly decreased ADP-induced blood platelet aggregation in a dose-dependent manner but increased the amplifying effect of serotonin on this process in rats.

Authors

ECEwa ChabielskaMedical University of Białystok BMBarbara MalinowskaMedical University of Białystok WBWłodzimierz BuczkoEdward F. Szczepanik State School of Higher Professional Education in Suwalki

Discussion

Member takes

Implication

May complicate ethanol's net hemostatic effects in humans; leaves open translation of rat platelet findings to clinical thrombosis or bleeding risk.

PICO

Intervention / Comparator

Ethanol (1.0, 2.0 and 4.0 g/kg p.o. (acute); 6 g/kg daily (chronic))

Primary Outcome

Blood platelet aggregation

Cite This Study

Chabielska et al. (2008) studied this question. Ethanol was evaluated on Blood platelet aggregation. Ethanol significantly decreased ADP-induced blood platelet aggregation in a dose-dependent manner but increased the amplifying effect of serotonin on this process in rats.

synapsesocial.com/papers/6a9cfcce18ccda70ef76f48b https://doi.org/10.1159/000138674

Topics

Dual antiplatelet therapy

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Implication

May complicate ethanol's net hemostatic effects in humans; leaves open translation of rat platelet findings to clinical thrombosis or bleeding risk.

Influence of Ethanol and Serotonin on Rat Platelet Aggregation

Discussion

Member takes

Implication

PICO

Cite This Study

Topics

Influence of Ethanol and Serotonin on Rat Platelet Aggregation

Discussion

Member takes

Implication

PICO

Cite This Study

Also Consider

Topics

Also Consider