Unilateral adrenalectomy for primary pigmented nodular adrenocortical disease may not prevent long-term complications of abnormal cortisol rhythms, such as severe osteopenia and myopathy.
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Unilateral adrenalectomy may not prevent late complications from persistent cortisol rhythm loss in PPNAD; leaves open whether rhythm-targeted strategies improve outcomes.
Nicholas J. Sarlis (1997) studied this question.
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