September 1, 1982CirculationOpen Access

Myocardial lactate and adenosine metabolite production as indicators of exercise-induced myocardial ischemia in the dog.

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Why the study?

Does myocardial production of lactate and adenosine metabolites indicate exercise-induced myocardial ischemia in a canine model?

Population

9 chronically instrumented dogs

Comparison

Exercise stress during reversible circumflex… vs Exercise stress before occlusion

Design

Preclinical

Authors

TVT VrobelUniversity School CJCharles R. JorgensenNorthwestern University RBRobert J. BacheAdult Congenital Heart Disease

Discussion

Member takes

Implication

Adenosine metabolites may outperform lactate for detecting ischemia in canine models; leaves open human translation.

Structured PICO

Does myocardial production of lactate and adenosine metabolites indicate exercise-induced myocardial ischemia in a canine model?

Population

9 chronically instrumented dogs

Intervention

Exercise stress during reversible circumflex coronary artery occlusion

Comparator

Exercise stress before occlusion

Outcome

Levels of lactate and adenosine metabolites (inosine and hypoxanthine) in arterial and coronary sinus bloodsurrogate

Myocardial production of adenosine metabolites is a sensitive marker of exercise-induced subendocardial ischemia in a canine model, outperforming lactate extraction.

Cite This Study

Vrobel et al. (1982) studied this question.

synapsesocial.com/papers/6a79ff3f4c448619ca0df79b https://doi.org/10.1161/01.cir.66.3.554

View Full Paper

Ask AI

Bookmark

Myocardial lactate and adenosine metabolite production as indicators of exercise-induced myocardial ischemia in the dog.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Myocardial lactate and adenosine metabolite production as indicators of exercise-induced myocardial ischemia in the dog.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider