November 19, 2001Catheterization and Cardiovascular Interventions
Reliability of fractional flow reserve measurements in patients with associated microvascular dysfunction: Importance of flow on translesional pressure gradient
Why the study?
Does microvascular dysfunction significantly affect the reliability of fractional flow reserve (FFR) measurements in patients with ischemic heart disease?
Population
Patients with ischemic heart disease undergoing intracoronary physiological assessment, comprising 19…
Comparison
Intracoronary pressure and flow recording using… vs Non-infarct-related lesions versus…
Design
Cross-sectional
Authors
Discussion
Loading...
Member takes
Implication
Severe microvascular dysfunction, such as that found post-myocardial infarction, has a limited effect on FFR calculations, supporting the reliability of standard FFR in this population.
Structured PICO
Does microvascular dysfunction significantly affect the reliability of fractional flow reserve (FFR) measurements in patients with ischemic heart disease?
P
Population
Patients with ischemic heart disease undergoing intracoronary physiological assessment, comprising 19 non-infarct-related lesions (part 1) and 21 non-infarct-related lesions compared to 22 matched infarct-related lesions (part 2).
I
Intervention
Intracoronary pressure and flow recording using a pressure and Doppler wire during maximal hyperemia and submaximal hyperemia (induced by low-dose adenosine).
C
Comparator
Non-infarct-related lesions (normal microcirculation) versus infarct-related lesions (severe microvascular dysfunction).
O
Outcome
Effect of coronary flow changes on translesional pressure gradient and fractional flow reserve (Pd/Pa).surrogate
Severe microvascular dysfunction, such as that found post-myocardial infarction, has a limited effect on FFR calculations, supporting the reliability of standard FFR in this population.
Cite This Study
Claeys et al. (2001) studied this question.