Key result
Low-dose aspirin use in elderly subjects is commonly associated with gastrointestinal injuries, and stopping its use leads to recovery.
Why the study?
While low-dose aspirin reduces cardiovascular risk, it is associated with gastrointestinal injuries such as ulcer and bleeding, particularly in sensitive populations like elderly subjects.
Does low-dose aspirin cause gastrointestinal injuries in elderly subjects?
Does low-dose aspirin cause gastrointestinal injuries in elderly subjects?
Gastroduodenal health should be carefully considered when recommending low-dose aspirin to elderly patients due to the risk of gastrointestinal injuries.
May warrant GI risk assessment with LDA in elderly patients; leaves open optimal prevention strategies from Level 5 data.
The use of low-dose aspirin (LDA) has been a common preventive measure to reduce the risk of cardiovascular events. This is attributed to aspirin's ability to inhibit platelet activation. On the other hand, the use of LDA in human subjects has been associated with the development of gastrointestinal injuries like ulcer and bleeding, especially for those sensitive subjects such as elder human subjects. This opinion review will summarize the recent clinical reports regarding the use of LDA and the development of gastrointestinal conditions in China. Based on these reports, it seems that the use of LDA is commonly associated with gastrointestinal injuries, and stopping its use leads to recovery in elderly subjects. Therefore, we would like to suggest that gastroduodenal health and conditions should be seriously taken into consideration when LDA is recommended to the elderly, or other alternative means to reduce the risk of cardiovascular events such as nutritional interventions should be suggested.
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Zhang et al. (2019) conducted a review in Cardiovascular events prevention. Low-dose aspirin was evaluated on Gastrointestinal injuries. Low-dose aspirin use in elderly subjects is commonly associated with gastrointestinal injuries, and stopping its use leads to recovery.
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