What question did this study set out to answer?

To investigate renal sodium excretion and hemodynamic mechanisms during high sodium intake in patients with severe heart disease lacking peripheral edema compared to those with edema.

September 1, 1956Journal of Clinical InvestigationOpen Access

The Relationship of Cardiovascular and Renal Hemodynamic Function to Sodium Excretion in Patients With Severe Heart Disease but Without Edema 12

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Authors

WHWilliam HollanderWeatherford College WJWalter E. JudsonIndiana University School of Medicine

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Implication

Comparative physiological study demonstrates preserved renal sodium excretion in non-edematous severe heart disease, suggesting hemodynamic differences dictate fluid retention.

Key Points

To investigate renal sodium excretion and hemodynamic mechanisms during high sodium intake in patients with severe heart disease lacking peripheral edema compared to those with edema.
Assessed renal excretion of sodium during moderately high sodium intake in cardiac patients presenting with dyspnea but no history of peripheral edema.
Measured cardiovascular and renal hemodynamic functions at rest and during exercise in non-edematous cardiac patients and compared them with edematous heart failure patients.
Non-edematous patients with severe heart disease demonstrated no obvious impairment in renal sodium excretion during moderate sodium loading.
Cardiovascular and renal hemodynamic profiles differed between non-edematous and edematous cohorts during rest and exercise, accounting for the variation in renal sodium handling.

Cite This Study

Hollander et al. (1956) studied this question.

synapsesocial.com/papers/6a7a044f74c579e25f89189a https://doi.org/10.1172/jci103357

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Implication

Comparative physiological study demonstrates preserved renal sodium excretion in non-edematous severe heart disease, suggesting hemodynamic differences dictate fluid retention.

The Relationship of Cardiovascular and Renal Hemodynamic Function to Sodium Excretion in Patients With Severe Heart Disease but Without Edema 12

Discussion

Member takes

Implication

Key Points

Cite This Study

The Relationship of Cardiovascular and Renal Hemodynamic Function to Sodium Excretion in Patients With Severe Heart Disease but Without Edema 12

Discussion

Member takes

Implication

Key Points

Cite This Study

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