Key result
Respiratory syncytial virus infection was associated with a significantly higher rate of hospitalization compared to overall acute respiratory infection cases (1.8% vs 0.6%; OR 3.8, 95% CI 3.0-4.9).
Why the study?
Viral acute respiratory infection remains a major global health problem among children in low- and middle-income countries, and the study aimed to reveal the aetiological significance of respiratory viruses among both non-hospitalized and hospitalized children.
Cohort (n=19,162)
Yes
Rhinovirus and respiratory syncytial virus are major viral etiologies of acute respiratory infections in Filipino children, with RSV significantly driving hospitalizations.
Answers are grounded in this paper and cite their sources.
Rhinovirus predominance across community-to-hospital ARI settings supports enhanced surveillance in LMIC children; leaves open virus-specific prevention strategies.
OBJECTIVES: Viral acute respiratory infection (ARI) remains a major global health problem, especially among children in low- and middle-income countries. The study was conducted to reveal aetiological significance of respiratory viruses among both non-hospitalized and hospitalized children. METHODS: A cohort study of children with ARI at the household, primary healthcare facility, and hospital levels was conducted alongside a hospital-based study including non-cohort children from 2014 to 2016 in the Philippines. The ARI cases were recorded at households and healthcare facilities, and a clinical investigation was performed. Nasopharyngeal swabs were collected from the symptomatic children and tested for respiratory viruses via polymerase chain reaction. Then, the association between healthcare facility utilization and viral detection was investigated. RESULTS: Overall, 18,514 ARI cases were enrolled in the cohort study, and samples were collected from 4735 of these cases. The hospital-based study detected 648 ARI cases, all of which were sampled. Rhinovirus (22.2%; 1052/4735) was most frequently detected followed by respiratory syncytial virus (12.0%; 566/4735). Enterovirus (adjusted odds ratio, 1.8; 95% confidence interval, 1.1-2.8), human metapneumovirus (2.1, 1.4-3.2), rhinovirus (2.1, 1.8-2.6), and respiratory syncytial virus (1.6, 1.2-1.9) were significantly more prevalent in the ARI cases at healthcare facilities than in those in households. Of all ARI cases, 0.6% required hospitalization while 1.8% were hospitalized among the respiratory syncytial virus-positive cases (3.8, 3.0-4.9). CONCLUSIONS: We determined the prevalence of respiratory viruses among children with ARIs at the household, primary healthcare facility, and hospital levels and the association with clinical characteristics. In particular, we discovered a significant disease burden and impact of respiratory syncytial virus infections as well as a considerable aetiological implication of rhinovirus infections.
No takes yet. Share an insight, caveat, or question.
Furuse et al. (2020) conducted a cohort in Acute respiratory viral infections (n=19,162). Respiratory syncytial virus infection vs. Overall acute respiratory infection cases was evaluated on Hospitalization (OR 3.8, 95% CI 3.0-4.9). Respiratory syncytial virus infection was associated with a significantly higher rate of hospitalization compared to overall acute respiratory infection cases (1.8% vs 0.6%; OR 3.8, 95% CI 3.0-4.9).
Synapse has enriched 10 related papers. Consider them for comparative context: