Population
HeLa, HepG2, and HuH7 cell lines
Comparison
Hydrogen peroxide exposure and eIF2alpha mutants vs Untreated cells / cap-dependent translation
Design
Preclinical
Authors
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Oxidative stress may selectively enhance HCV translation in hepatocytes; hypothesis-generating and requires in vivo validation before clinical relevance.
Oxidative stress modulates HCV IRES-mediated translation in a cell-type dependent manner, involving eIF2alpha phosphorylation.
MacCallum et al. (2006) studied this question.
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