Why the study?
Does atrial stretch after blockade of the atrial receptor reflex cause natriuresis attributable to ANP in anesthetized dogs?
Population
11 chloralose anaesthetized dogs
Comparison
Distension of a balloon in the left atrium with… vs Distension of a balloon in the left atrium with…
Design
Preclinical
Authors
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ANP release from atrial stretch may not drive natriuresis without reflex pathways in dogs; leaves open its physiological natriuretic role.
Does atrial stretch after blockade of the atrial receptor reflex cause natriuresis attributable to ANP in anesthetized dogs?
Atrial stretch-induced ANP release does not cause natriuresis when the atrial receptor reflex is blocked, questioning its physiological role as a natriuretic hormone.
Knapp et al. (1986) studied this question.
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