Orphaned mitochondria in heart failure
Key result
In a guinea pig model of systolic heart failure, down-regulation of Mfn1 and Mfn2 leads to spatial disorganization of mitochondria and impaired mitochondrial network behavior.
Population
guinea pig model of systolic heart failure (failing cardiac myocytes)
Design
Editorial
Authors
Discussion
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Member takes
Implication
The editorial highlights that structural disorganization of the mitochondrial network due to Mfn1/2 downregulation in heart failure impairs critical ROS signaling and bioenergetics.
Structured PICO
P
Population
guinea pig model of systolic heart failure (failing cardiac myocytes)
C
Comparator
non-failing cardiac myocytes
O
Outcome
mitochondrial network behavior and ROS-induced ROS releasesurrogate
The editorial highlights that structural disorganization of the mitochondrial network due to Mfn1/2 downregulation in heart failure impairs critical ROS signaling and bioenergetics.
Cite This Study
Christoph Maack (2015) conducted an editorial in Heart failure. In a guinea pig model of systolic heart failure, down-regulation of Mfn1 and Mfn2 leads to spatial disorganization of mitochondria and impaired mitochondrial network behavior.