Key result
Whole-body temperature variations (4-43°C) altered blood pressure and heart rate patterns in normotensive rats depending on the amplitude, suddenness, and duration of the change.
Why the study?
Data from studies using rat models were combined to evaluate how whole-body hypothermia and hyperthermia affect cardiovascular function and hemodynamic parameters in normotensive conscious adult rats.
Meta-Analysis
In normotensive rats, cardiovascular adaptive responses to temperature variations are complex and depend on the specific characteristics of the temperature change and environmental conditions.
Rat model findings on temperature effects warrant caution before clinical use; leaves open translation to human hemodynamics.
Abstract—In this paper we focus on a meta-analysis where the data from studies using rat models are combined to evaluate the effects of hypothermia and hyperthermia on the cardiovascular function. For this meta-analysis, 25 articles from the PubMed database were selected. The research aim of these reports was to investigate how whole-body hypothermia and hyperthermia in normotensive conscious adult rats affect hemodynamic parameters (systemic blood pressure and heart rate). The effects of short-term severe hyperthermia (40–43°C), prolonged moderate hyperthermia (32–34°C), and short-term and prolonged hypothermia (4–9°C, sudden and gradual, with and without any changes in photoperiod) were investigated. It has been shown that the blood pressure and heart rate patterns in normotensive conscious rats in response to a change in the ambient temperature are determined according not only to the vector field showing the direction of temperature change, but also to the amplitude, suddenness, duration of the change, and concomitant conditions (e.g., the duration of photoperiod).
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Kuzmenko et al. (2021) conducted a meta-analysis in Normotensive. Temperature variations (hypothermia and hyperthermia) was evaluated on Hemodynamic parameters (systemic blood pressure and heart rate). Whole-body temperature variations (4-43°C) altered blood pressure and heart rate patterns in normotensive rats depending on the amplitude, suddenness, and duration of the change.
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