Key result
A prototype tissue-engineered heart valve constructed using the self-assembly method demonstrated the capacity to open and close according to flow variations under a light pulsatile flow of 0.5 Hz.
Population
In vitro model using fibroblast sheets produced with the self-assembly technique
Design
Preclinical
Authors
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Hypothesis-generating for self-assembled biological heart valves; requires in vivo durability testing before clinical translation.
The self-assembly method can successfully create entirely biological, stentless tissue-engineered heart valves capable of functioning under pulsatile flow in a bioreactor.
Tremblay et al. (2014) studied Heart valve replacement. Tissue-engineered heart valve using the self-assembly method was evaluated on Behavior in a bioreactor when exposed to a pulsatile flow. A prototype tissue-engineered heart valve constructed using the self-assembly method demonstrated the capacity to open and close according to flow variations under a light pulsatile flow of 0.5 Hz.
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