Key result
A multiple-step injection molding process successfully enabled the fabrication of tissue-engineered heart valves with heterogeneous composition of wall and leaflets without the need for gluing or suturing.
Population
Tissue-engineered heart valves (fibrin-based scaffolds and cell lines)
Design
Preclinical
Follow-up
2 weeks
Authors
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May enable complex tissue-engineered heart valves; leaves open in vivo durability and clinical translation.
A novel multiple-step injection molding method enables the fabrication of tissue-engineered heart valves with heterogeneous composition, mimicking natural structural complexity without the need for suturing or gluing.
Weber et al. (2015) studied Tissue-engineered heart valves. Multiple-step injection molding was evaluated on Fabrication of TEHVs with heterogeneous composition of wall and leaflets. A multiple-step injection molding process successfully enabled the fabrication of tissue-engineered heart valves with heterogeneous composition of wall and leaflets without the need for gluing or suturing.
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