Key result
In patients with hypertrophic cardiomyopathy, real-time three-dimensional ultrasonography revealed that the severity of left ventricular diastolic dyssynchrony was positively correlated with systolic dyssynchrony (r=0.413, P<0.05).
Why the study?
Can single-cardiac real-time three-dimensional ultrasonography effectively evaluate the relationship between left ventricular diastolic and systolic dyssynchrony in patients with hypertrophic cardiomyopathy?
Case-Control (n=104)
No
Can single-cardiac real-time three-dimensional ultrasonography effectively evaluate the relationship between left ventricular diastolic and systolic dyssynchrony in patients with hypertrophic cardiomyopathy?
Effect estimate: r=0.413
p-value: p=<0.05
Single-cardiac real-time three-dimensional ultrasonography demonstrates that the severity of diastolic dyssynchrony is positively correlated with systolic dyssynchrony in patients with hypertrophic cardiomyopathy.
Diastolic-systolic dyssynchrony correlation in HCM supports 3D echo evaluation; leaves open prospective validation before any clinical adoption.
The relationship between left ventricular diastolic and systolic dyssynchrony in hypertrophic cardiomyopathy (HCM) was investigated by single-cardiac real-time three-dimensional ultrasonography. A total of 52 patients with HCM were selected in Jining No. 1 People's Hospital from July 2016 to June 2017. Additionally, a total of 52 healthy people were selected to serve as the control group. All participants received real-time two- and three-dimensional ultrasonography to evaluate left ventricular morphology, function and systolic and diastolic function. The relevant parameters included left ventricular end-diastolic volume (LVEDV), left ventricular end-systolic volume (LVESV), left ventricular ejection fraction (LVEF), end-systolic/diastolic sphericity index (ESSI/EDSI), systolic dyssynchrony index (SDI), diastolic dyssynchrony index (DDI), dispersion end systole (DISPES), diastolic dyssynchrony index-late (DDI-late) and dispersion end diastole (DISPED-late). The LVEF of observation group was significantly lower than that of the control group, while LVEDV, LVESV, E/A and E/Ea were significantly higher than those in control group (P<0.05); EDSI, DDI-late and DISPED-late were significantly higher in observation than in control group (P<0.05); ESSI, SDI and DISPES in observation were significantly higher than those in control group (P<0.05); The 16-segment time-volume curve of observation group was disordered without synchronization, while the curve of control group was regular and smooth with synchronization; Pearson's correlation analysis showed that SDI and DDI were positively correlated (P<0.05). In conclusion, three-dimensional ultrasonography can be used to effectively evaluate left ventricular diastolic and systolic dyssynchrony in HCM. The severity of diastolic is positively correlated with systolic dyssynchrony.
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Xing et al. (2018) conducted a case-control in Hypertrophic cardiomyopathy (n=104). Hypertrophic cardiomyopathy vs. Healthy controls was evaluated on Correlation between systolic dyssynchrony index (SDI) and diastolic dyssynchrony index (DDI) (r=0.413, p=<0.05). In patients with hypertrophic cardiomyopathy, real-time three-dimensional ultrasonography revealed that the severity of left ventricular diastolic dyssynchrony was positively correlated with systolic dyssynchrony (r=0.413, P<0.05).
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