Key result
Remimazolam induction resulted in a significantly lower incidence of hypotension and better preservation of blood pressure compared to propofol in hypertensive patients.
Why the study?
Hypertensive patients experience more profound hemodynamic variations and higher risk of hypoperfusion-induced organ damage from hypotensive episodes during general anesthesia induction than normotensive patients.
Does remimazolam improve hemodynamic stability compared to propofol during general anesthesia induction in hypertensive patients?
Comparison
Remimazolam vs propofol
Design
Randomized trial
Follow-up
5 minutes after tracheal intubation
Authors
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Remimazolam may confer greater hemodynamic stability than propofol during induction in hypertensive patients; leaves open whether this reduces organ injury or warrants practice change.
RCT (n=96)
Does remimazolam improve hemodynamic stability compared to propofol during general anesthesia induction in hypertensive patients?
Remimazolam provides better hemodynamic stability and a lower incidence of hypotension compared to propofol during anesthesia induction in hypertensive patients.
Choi et al. (2023) conducted an RCT in Hypertension requiring general anesthesia (n=96). Remimazolam vs. Propofol was evaluated on Hemodynamic parameters (MBP, SBP, DBP, HR) and incidence of hypotension. Remimazolam induction resulted in a significantly lower incidence of hypotension and better preservation of blood pressure compared to propofol in hypertensive patients.
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