November 10, 2000Circulation ResearchOpen Access

Calmodulin Kinases II and IV and Calcineurin Are Involved in Leukemia Inhibitory Factor–Induced Cardiac Hypertrophy in Rats

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Population

Primary cultured rat neonatal cardiomyocytes and adult rat cardiomyocytes

Design

Preclinical

Authors

TKTakahiro KatōFukushima Medical University MSMotoaki SanoHeart Failure & Transplant SMShunichiro MiyoshiKeio University Hospital

Discussion

Member takes

Implication

Hypothesis-generating for LIF hypertrophy signaling in vitro; in vivo and human studies needed before therapeutic consideration.

Structured PICO

Population

Primary cultured rat neonatal cardiomyocytes and adult rat cardiomyocytes

Intervention

Leukemia inhibitory factor (LIF)

Outcome

Activation of calcineurin, CaMKII, and CaMKIV, and markers of cardiac hypertrophy ([(3)H]phenylalanine uptake, cell size, and gene expression)surrogate

LIF-induced cardiac hypertrophy in rat cardiomyocytes is mediated by the activation of CaMKII, CaMKIV, and calcineurin through increased intracellular calcium.

Cite This Study

Katō et al. (2000) studied this question.

synapsesocial.com/papers/6a7a62f9b9dd6cc1fe0dbb4f https://doi.org/10.1161/01.res.87.10.937

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