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January 1, 2001Scandinavian Cardiovascular JournalOpen Access

99m Tc-Sestamibi SPECT is a Useful Technique for Viability Detection. Results of a Comparison with NH 3 /FDG PET

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Why the study?

Does 99mTc-Sestamibi SPECT accurately detect myocardial viability compared to NH3/FDG PET in patients with ischemic cardiomyopathy?

Population

50 patients with ischemic cardiomyopathy, mean age 57+/-7 years, ejection fraction 28 +/- 8%.

Comparison

99mTc-Sestamibi Single Photon Emission… vs Positron Emission Tomography with 13N-ammonia…

Design

Cross-sectional, Patients underwent SPECT and PET imaging in random order

Authors

APAnne Kaltoft, Morten Bøttcher, Niels Pet

Discussion

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Implication

SPECT may offer a practical alternative to PET for viability assessment in ischemic cardiomyopathy; leaves open need for prospective outcome validation.

Structured PICO

Does 99mTc-Sestamibi SPECT accurately detect myocardial viability compared to NH3/FDG PET in patients with ischemic cardiomyopathy?

P
Population
50 patients with ischemic cardiomyopathy, mean age 57+/-7 years, ejection fraction 28 +/- 8%.
I
Intervention
99mTc-Sestamibi Single Photon Emission Computerized Tomography (SPECT)
C
Comparator
Positron Emission Tomography (PET) with 13N-ammonia (NH3) and 18F-fluoro-deoxy-glucose (FDG)
O
Outcome
Concordance of myocardial viability detection (sensitivity, specificity, positive and negative predictive values) compared to PETsurrogate

99mTc-Sestamibi SPECT provides an acceptable, more readily available alternative to NH3/FDG PET for delineating myocardial viability in patients with severe ischemic cardiomyopathy.

Cite This Study

Anne Kaltoft, Morten Bøttcher, Niels Pet (2001) studied this question.

synapsesocial.com/papers/6a7a734b8d250a4360f40b95https://doi.org/10.1080/14017430152581350

Topics

CardiomyopathyCoronary artery disease
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Also Consider

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  1. 1Feasibility of tomographic 99mTc-hexakis-2-methoxy-2-methylpropyl-isonitrile imaging for the assessment of myocardial area at risk and the effect of treatment in acute myocardial infarction.1989 · 319 citations
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  3. 3Comparison of sestamibi single-photon emission computed tomography with positron emission tomography for estimating left ventricular myocarclial viability1995 · 106 citations
  4. 4Comparison of Thallium-201 Resting Redistribution With Technetium-99m–Sestamibi Uptake and Functional Response to Dobutamine for Assessment of Myocardial Viability1995 · 50 citations
  5. 5Are the kinetics of technetium-99m methoxyisobutyl isonitrile affected by cell metabolism and viability?1990 · 184 citations