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April 1, 1998Clinical CardiologyOpen Access

Are technetium‐99m‐labeled myocardial perfusion agents adequate for detection of myocardial viability?

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Key result

Technetium-99m perfusion imaging agents can be successfully employed for the determination of myocardial viability in patients with severe regional dysfunction and chronic coronary artery disease.

Why the study?

Are technetium-99m-labeled myocardial perfusion agents adequate for the detection of myocardial viability compared to Thallium-201 in patients with ischemic cardiomyopathy?

Population

Patients with coronary artery disease and depressed left ventricular function (ischemic cardiomyopathy)

Comparison

Technetium-99m perfusion agents vs Thallium-201 (201Tl) imaging

Design

Review

Authors

BCBiray CanerGBGeorge Beller

Discussion

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Overview

Supports technetium-99m viability imaging in chronic CAD; leaves open prospective trials versus thallium-201.

Structured PICO

Are technetium-99m-labeled myocardial perfusion agents adequate for the detection of myocardial viability compared to Thallium-201 in patients with ischemic cardiomyopathy?

P
Population
Patients with coronary artery disease and depressed left ventricular function (ischemic cardiomyopathy)
I
Intervention
Technetium-99m (99mTc) perfusion agents (99mTc-sestamibi and 99mTc-tetrofosmin)
C
Comparator
Thallium-201 (201Tl) imaging
O
Outcome
Detection of myocardial viabilitysurrogate

Technetium-99m-labeled agents are valid alternatives to Thallium-201 for assessing myocardial viability in patients with ischemic cardiomyopathy.

Limitations

  • Attenuation of 99mTc-sestamibi and 99mTc-tetrofosmin is greatest in the inferior wall region, making determination of viability problematic in this area.

Cite This Study

Caner et al. (1998) conducted a review in Coronary artery disease and depressed left ventricular function. Technetium-99m-labeled myocardial perfusion agents (99mTc-sestamibi and 99mTc-tetrofosmin) vs. Thallium-201 (201Tl) was evaluated on Detection of myocardial viability. Technetium-99m perfusion imaging agents can be successfully employed for the determination of myocardial viability in patients with severe regional dysfunction and chronic coronary artery disease.

synapsesocial.com/papers/6aa00bbf603ff62333619536https://doi.org/10.1002/clc.4960210402
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Myocardial kinetics of technetium-99m-hexakis-2-methoxy-2-methylpropyl-isonitrile.1988 · 381 citations
  2. 2Myocardial viability in patients with chronic coronary artery disease. Comparison of 99mTc-sestamibi with thallium reinjection and [18F]fluorodeoxyglucose.1994 · 272 citations