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June 1, 1995The American Journal of CardiologyOpen Access

Comparison of sestamibi single-photon emission computed tomography with positron emission tomography for estimating left ventricular myocarclial viability

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Authors

RSRobert SouferHDHolley M. DeyCNChin K. Ng

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Overview

Comparative imaging study reveals sestamibi SPECT underestimates myocardial viability compared with PET in coronary artery disease, suggesting PET utility for inferior wall assessment.

Key Points

  • To compare resting technetium-99m sestamibi SPECT with FDG PET for assessing regional myocardial viability and predicting functional recovery following revascularization.
  • Evaluated 37 patients with coronary artery disease using resting technetium-99m sestamibi SPECT, N-13 ammonia/18FDG PET, and radionuclide ventriculography.
  • Performed segmental concordance analysis between sestamibi and FDG, assessing pre- and post-revascularization regional ejection fraction in discordant segments.
  • Concordance between sestamibi SPECT and FDG PET occurred in 71% of myocardial segments (102 viable and 29 nonviable concordant segments).
  • Discordance where segments were sestamibi nonviable but FDG viable was localized predominantly to the inferior myocardial wall.
  • In segments classified as nonviable by sestamibi, FDG PET predicted significant regional functional recovery after revascularization, with regional ejection fraction increasing from 36% (±5 SE) preoperatively to 48% (±5.5 SE) postoperatively (p < 0.0006).

Cite This Study

Soufer et al. (1995) studied this question.

synapsesocial.com/papers/6aaa593e346271c31733b650https://doi.org/10.1016/s0002-9149(99)80765-6
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