Why the study?
Does sublingual verapamil provide comparable pharmacokinetics and AV nodal conduction delay compared to intravenous verapamil in healthy volunteers?
Population
n=7 healthy human volunteers
Comparison
Sublingual verapamil 40 mg or 60 mg vs Intravenous verapamil 5 mg
Follow-up
480 minutes after each dose
Authors
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Sublingual verapamil should not replace IV for acute AV nodal effects; leaves open need for effective nonparenteral formulations.
Does sublingual verapamil provide comparable pharmacokinetics and AV nodal conduction delay compared to intravenous verapamil in healthy volunteers?
Sublingual verapamil has little clinical utility compared to intravenous administration due to slower onset, lesser pharmacologic effect on AV nodal conduction, and poor tolerance.
Berk et al. (1992) studied this question.
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