Why the study?
Elucidating cardiac heterogeneity and cell-to-cell interactions is needed to clarify the pathogenesis of diabetic myocardial fibrosis and identify therapeutic targets.
Single-cell RNA sequencing identifies the Pdgfra axis and Itgb1 as key intercellular communication drivers and potential therapeutic targets for myocardial fibrosis in diabetic cardiomyopathy.
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Hypothesis-generating for intercellular fibrosis drivers in diabetic cardiomyopathy; leaves open human translation pending validation.
Li et al. (2023) studied this question.
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