Population
35 healthy male volunteers
Design
Cohort
Follow-up
17 hours (from 08.00 H up to 01.00 H)
Authors
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May warrant time-of-day consideration in ECG interpretation; hypothesis-generating for adjusted references in clinical populations.
Significant diurnal variations exist in ECG parameters, particularly T wave amplitudes and QTc intervals, in healthy males, which should be considered when interpreting ECGs.
Koch et al. (1999) studied this question.
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