Population
Embryonic heart models (Tbx2Cre allele lineage tracing and Tbx2-deficient embryos)
Design
Preclinical
Authors
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Hypothesis-generating for congenital defects from atrioventricular canal errors; extends lineage mapping but requires human validation.
Tbx2+ primary myocardium contributes extensively to the ventricles and atrioventricular node, suggesting that early atrioventricular canal developmental errors may impact the ventricular base.
Aanhaanen et al. (2009) studied this question.
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