Effects of pimobendan in cats with hypertrophic cardiomyopathy and recent congestive heart failure: Results of a prospective, double-blind, randomized, nonpivotal, exploratory field study

Figures

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  FIGURE 1. Flow chart on enrollment of cats, stratification, randomization, and analysis sets

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  FIGURE 2. Effect of pimobendan (A,C) and placebo (B,D) on left ventricular outflow tract obstruction in cats with obstructive (A,B) and nonobstructive (C,D) HCM 2‐5 hours after administration of the medication on D0. There was no difference (P > .05) between groups and time points (all panels). PG, pressure gradien

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  FIGURE 3. Left ventricular outflow tract pressure gradient (PG) after administration of pimobendan (left) or placebo (right) on D0, D10, D60, and D180 in cats with obstructive HCM that successfully completed the study. The PG over time decreased after pimobendan (P = .009) and placebo (P = .001). The increments on the X‐axis are not synchronized to the true time period

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  FIGURE 4. Odds ratios and 95% confidence intervals (CI) for the difference between treatment groups (pimobendan vs placebo) for a successful outcome at D180 for the overall FAS population and for cats with and without LVOTO. Three cats in the LVOTO group were removed from the study on D0 because of an increase in LVOT systolic pressure gradient after a single dose of pimobendan

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  FIGURE 5. Kaplan‐Meier curves of the time to study failure (ie, died, withdrawn from the study, or increase in furosemide dose) for the FAS population in the 2 treatment groups. 51/76 (67.1%) cats reached the endpoint. +, censored. Hazards ratio (HR), 0.96; 95% confidence interval (CI), 0.54 to 1.71

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  FIGURE 6. Kaplan‐Meier curves of the time to study failure for the FAS population of cats with (A) and without (B) left ventricular outflow tract obstruction (LVOTO) in the 2 treatment groups. 16/29 (55.2%) cats with LVOTO (hazards ratio [HR], 3.136; 95% confidence interval [CI], 1.13‐8.73) and 35/47 (74.5%) cats without LVOTO (HR, 0.553; 95% CI, 0.28 to 1.10) reached the endpoint. +, censored. Three cats in the LVOTO group were removed from the study on D0 because of an increase in LVOT systolic pressure gradient after a single dose of pimobendan

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  FIGURE 7. Kaplan‐Meier curves of the time‐to‐event analysis of cardiac morbidity and mortality (cardiac death, cardiac euthanasia, and furosemide dose >10 mg/kg/d) for the full analysis set (FAS) population. 9/39 cats on pimobendan and 10/37 cats on placebo reached the secondary end‐point. +, censored