Population
Rat hearts (perfused) and in vivo rats
Comparison
Perfusion with long-chain fatty acids at fasting… vs Perfusion with 5 mm glucose without fatty acids
Design
Preclinical
Follow-up
1 h (perfusion) or 24 h (starvation)
Authors
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Fatty acid activation of cardiac AMPK in animals warrants clinical caution; leaves open feed-forward mechanisms in human heart disease.
Physiological concentrations of long-chain fatty acids covalently activate heart AMPK, providing a potential feed-forward mechanism for fatty acid oxidation.
Clark et al. (2004) studied this question.
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