What question did this study set out to answer?

To assess the feasibility, safety, and responsiveness of an implantable pacemaker controlled by right atrial oxygen saturation in a human subject.

November 1, 1988Pacing and Clinical Electrophysiology

First Clinical Experience with an Oxygen Saturation Controlled Pacemaker in Man

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Why the study?

Does an implantable pacemaker controlled by right atrial oxygen saturation provide appropriate rate response and hemodynamic feedback in humans?

Key Points

To assess the feasibility, safety, and responsiveness of an implantable pacemaker controlled by right atrial oxygen saturation in a human subject.
Monitored an implantable pacemaker regulated by right atrial oxygen saturation during a 5-month observation period to detect potential sensor malfunction from tissue ingrowth.
Conducted multiple exercise stress tests to quantify response speed, decay times, and rate linearity.
Measured cardiac output to examine hemodynamic feedback and the self-optimization capacity of the pacing rate.
No device malfunction or sensor failure due to tissue growth occurred during the 5-month follow-up.
The pacing rate adapted rapidly to exercise onset within 5 s to 17 s, increasing linearly with applied stress load, with decay times proportional to prior workload.
Cardiac output evaluations confirmed active hemodynamic feedback and effective self-optimization of pacing rates.

Structured PICO

Does an implantable pacemaker controlled by right atrial oxygen saturation provide appropriate rate response and hemodynamic feedback in humans?

Population

Humans (first clinical experience in man)

Intervention

Implantable pacemaker controlled by right atrial oxygen saturation

Outcome

Device function, reaction to exercise changes, and malfunction due to tissue growthsurrogate

The first clinical experience with a right atrial oxygen saturation-controlled pacemaker demonstrated appropriate hemodynamic feedback, quick reaction times to exercise, and no early malfunction.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

First-in-human case supports oxygen saturation sensing feasibility; leaves open validation in prospective trials before practice change.

Cite This Study

Stangl et al. (1988) studied this question.

synapsesocial.com/papers/6a7ab65b4c448619ca0e45e0 https://doi.org/10.1111/j.1540-8159.1988.tb06324.x

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First Clinical Experience with an Oxygen Saturation Controlled Pacemaker in Man

Key Points

Structured PICO

Discussion

Implication

Cite This Study

First Clinical Experience with an Oxygen Saturation Controlled Pacemaker in Man

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider