Why the study?
Do atrial flow dynamics such as incomplete venous occlusion and mitral regurgitation affect tissue temperature during balloon cryoablation?
Population
In vitro pulmonary vein phantom constructed from bovine muscle with a 20 mm vein ostium
Comparison
Controlled cryoablations using a 2nd generation… vs Different simulated flow conditions
Design
Preclinical
Authors
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Flow dynamics may alter tissue cooling in vitro; leaves open optimal occlusion strategies for clinical PVI.
Do atrial flow dynamics such as incomplete venous occlusion and mitral regurgitation affect tissue temperature during balloon cryoablation?
Incomplete venous occlusion and mitral regurgitation significantly impair cryoablation effectiveness, demonstrating that balloon temperature is a poor indicator of tissue temperature under high flow conditions.
Ghosh et al. (2017) studied this question.
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