Why the study?
Do real-time in vivo microvascular abnormalities correlate with biochemical markers of inflammation and endothelial dysfunction in patients with Type-1 Diabetes Mellitus?
Population
Patients with Type-1 Diabetes Mellitus (T1DM) and healthy non-diabetic controls
Design
Case-control
Authors
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May support intravital microscopy for tracking endothelial dysfunction in T1DM; leaves open validation in prospective cohorts before clinical use.
Do real-time in vivo microvascular abnormalities correlate with biochemical markers of inflammation and endothelial dysfunction in patients with Type-1 Diabetes Mellitus?
Specific microvascular abnormalities assessed by intravital microscopy correlate with biochemical markers of endothelial dysfunction in T1DM, suggesting their potential utility as physiologic markers in disease progression.
Cheung et al. (2009) studied this question.
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