December 1, 1983Circulation Research

Coexistence of beta 1- and beta 2-adrenoceptors in human right atrium. Direct identification by (+/-)-125Iiodocyanopindolol binding.

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Population

Membranes from human right atrial appendage obtained during open heart surgery (n=4 for binding experiments)

Design

Preclinical

Authors

OBOtto‐Erich BroddeHalle Institute for Economic Research KKK KaradUniversity of Kara HZH.–R. ZerkowskiWilhelminen Hospital

Discussion

Member takes

Implication

Should not yet guide beta-blocker selection in atrial disease; leaves open functional validation of the 80:20 ratio in human cohorts.

Structured PICO

Population

Membranes from human right atrial appendage obtained during open heart surgery (n=4 for binding experiments)

Intervention

(+/-)-[125I]iodocyanopindolol binding and displacement by beta-adrenergic agonists and antagonists

Outcome

Beta-adrenoceptor subclassification and beta 1:beta 2 ratiosurrogate

This study demonstrates that beta 1- and beta 2-adrenoceptors coexist in the human right atrium, with beta 1-adrenoceptors predominating at an 80:20 ratio.

Cite This Study

Brodde et al. (1983) studied this question.

synapsesocial.com/papers/6a7ae1ede357fbdac589b2dd https://doi.org/10.1161/01.res.53.6.752

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Coexistence of beta 1- and beta 2-adrenoceptors in human right atrium. Direct identification by (+/-)-125Iiodocyanopindolol binding.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Coexistence of beta 1- and beta 2-adrenoceptors in human right atrium. Direct identification by (+/-)-125Iiodocyanopindolol binding.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider