February 3, 2015Hypertension
Age-Related Difference in the Sleep Pressure-Lowering Effect Between an Angiotensin II Receptor Blocker and a Calcium Channel Blocker in Asian Hypertensives
Key result
Amlodipine 5 mg achieved a significantly greater reduction in sleep, awake, and 24-hour blood pressure compared with azilsartan 20 mg over 8 weeks in Asian hypertensive patients.
Why the study?
Does azilsartan 20 mg compared to amlodipine 5 mg reduce sleep blood pressure in Asian hypertensives?
Population
Asian hypertensive patients (including elderly subgroup aged ≥60 years old)
Comparison
Azilsartan 20 mg oral for 8 weeks vs Amlodipine 5 mg oral for 8 weeks
Design
RCT, randomized, 2-parallel-group, open-label
Follow-up
8 weeks
Authors
Discussion
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Implication
Amlodipine 5 mg may be prioritized over azilsartan 20 mg in Asian hypertensives; extends head-to-head ambulatory BP data versus ARBs.
Study Design
Type
RCT
Blinding
Open-label
Randomization
randomized
Multicenter
Yes
Structured PICO
Does azilsartan 20 mg compared to amlodipine 5 mg reduce sleep blood pressure in Asian hypertensives?
P
Population
Asian hypertensive patients treated for 8 weeks to compare the efficacy of azilsartan and amlodipine on sleep blood pressure.
I
Intervention
Azilsartan 20 mg oral for 8 weeks
C
Comparator
Amlodipine 5 mg oral for 8 weeks
O
Outcome
Sleep blood pressure evaluated by ambulatory BP monitoring at 8 weekssurrogate
Amlodipine 5 mg provides significantly greater reduction in sleep, awake, and 24-hour blood pressure compared to azilsartan 20 mg in Asian hypertensives, supporting guideline recommendations for its use in the elderly.
Cite This Study
Kario et al. (2015) conducted an RCT in Hypertension. Amlodipine vs. Azilsartan 20 mg was evaluated on Sleep blood pressure evaluated by ambulatory BP monitoring. Amlodipine 5 mg achieved a significantly greater reduction in sleep, awake, and 24-hour blood pressure compared with azilsartan 20 mg over 8 weeks in Asian hypertensive patients.