Why the study?
Does aging alter cerebral artery tone and [Ca2+]i responses in isolated rat cerebral arteries?
Does aging alter cerebral artery tone and [Ca2+]i responses in isolated rat cerebral arteries?
Aging alters cerebral artery tone and intracellular calcium responses through both NO synthase-sensitive and -insensitive mechanisms, potentially contributing to age-dependent shifts in cerebral blood flow autoregulation.
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May indicate age-related shifts in rat cerebral autoregulation; leaves open translation to human aging and clinical relevance.
Geary et al. (2003) studied this question.
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