Why the study?
Does excessive circadian blood pressure amplitude increase the risk of ischaemic stroke and nephropathy?
Population
297 subjects, including 176 treated patients with an elevated blood pressure mean (MESOR-hypertensives)
Comparison
Excessive circadian blood pressure amplitude vs Normal circadian blood pressure amplitude
Design
Cohort
Follow-up
6 years
Authors
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May support 24-hour BP variability assessment in at-risk patients; hypothesis-generating and should not yet change practice.
Does excessive circadian blood pressure amplitude increase the risk of ischaemic stroke and nephropathy?
Excessive circadian blood pressure amplitude is an independent risk factor for adverse vascular events such as ischaemic stroke and nephropathy, highlighting the importance of 24-hour blood pressure variability management.
Otsuka et al. (1997) studied this question.
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