Population
34 patients with stable chronic obstructive pulmonary disease and 8 age-matched healthy control subjects
Design
Case-control
Authors
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Muscle energy metabolite differences in stable COPD should not yet change practice; hypothesis-generating for symptom mechanisms and needs prospective validation.
Patients with stable COPD exhibit elevated IMP levels and lower ATP/ADP ratios in resting muscle, suggesting an imbalance in energy metabolism.
Pouw et al. (1998) studied this question.
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