Key result
Uncontrolled and resistant arterial hypertension were associated with significantly deteriorated myocardial work compared to controls and well-controlled hypertension.
Why the study?
The study was conducted to examine myocardial performance using pressure-strain loops in hypertensive patients with different levels of blood pressure control.
Is myocardial work associated with functional capacity in patients with arterial hypertension?
Cross-Sectional (n=204)
Is myocardial work associated with functional capacity in patients with arterial hypertension?
In patients with arterial hypertension, myocardial work is deteriorated in uncontrolled and resistant cases and is independently associated with functional capacity.
May indicate subclinical LV dysfunction in uncontrolled hypertension; leaves open whether tighter BP control improves myocardial work.
PURPOSE: The aim of this study was to examine myocardial performance using pressure-strain loops in hypertensive patients with different level of blood pressure control. MATERIAL AND METHODS: This cross-sectional study included 204 subjects (45 controls, 70 patients with well-controlled hypertension, 58 patients with uncontrolled hypertension and 31 patients with resistant hypertension) who underwent complete two-dimensional echocardiographic examination including two-dimensional speckle-tracking echocardiography. Pressure-strain curve was used to determine global myocardial work, constructive work, wasted work and work efficiency in all study participants. RESULTS: Left ventricular (LV) longitudinal strain gradually reduced from controls throughout well-controlled hypertensive patients, to patients with uncontrolled and resistant hypertension. Global myocardial work was higher in patients with uncontrolled and resistant hypertension than in controls and well-controlled hypertension. Constructive work was also higher in all hypertensive patients than in controls. Global wasted work and work efficiency were similar between different groups. Global myocardial work index was associated with peak oxygen consumption independently of sex, age, body mass index (BMI), LV structural and functional parameters in all hypertensive participants. CONCLUSIONS: Myocardial work was significantly deteriorated in patients with uncontrolled and resistant arterial hypertension compared to controls and well-controlled hypertensive patients. Global myocardial work was associated with functional capacity independent of clinical and echocardiographic parameters.
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Tadić et al. (2021) conducted a cross-sectional in arterial hypertension (n=204). Uncontrolled and resistant hypertension vs. Controls and well-controlled hypertension was evaluated on Global myocardial work, constructive work, wasted work and work efficiency. Uncontrolled and resistant arterial hypertension were associated with significantly deteriorated myocardial work compared to controls and well-controlled hypertension.
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