Population
6-day-old piglets
Comparison
Intravenous administration of Doxorubicin to… vs Control hearts
Design
Preclinical
Authors
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Hypothesis-generating in piglet diastolic HF; leaves open chamber-specific ANKRD1 as a human therapeutic target.
In a piglet model of diastolic heart failure, ANKRD1 gene expression is oppositely regulated, being upregulated in the ventricles and downregulated in the atria.
Torrado et al. (2006) studied this question.
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