Population
Rat cardiac tissue samples (sham-operated and 6-week post-myocardial infarction)
Comparison
cDNA microarrays for gene expression profiling vs Sham-operated samples
Design
Preclinical
Follow-up
6 weeks post-MI
Authors
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Supports hypothesis generation on myocardial gene regulation; leaves open translation to human therapeutics pending validation.
cDNA microarrays can successfully identify novel gene expression changes and monitor the evolution of the cardiac stress-inducible phenotype post-MI in rat models.
Sehl et al. (2000) studied this question.
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