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April 27, 2000Physiological Genomics

Gene expression profile in mouse myocardium after ischemia

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Population

Mouse heart model with surgical constriction of the left coronary artery without reperfusion

Comparison

24-hour ischemia vs Control tissue

Design

Preclinical

Follow-up

24 hours

Authors

DLDeborah LynMorehouse School of MedicineXLXiaowei LiuShanghai East HospitalNBNicole A. BennettMorehouse School of Medicine

Discussion

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Implication

Highlights molecular drivers of post-ischemic remodeling in mice; leaves open translation to human outcomes.

Structured PICO

P
Population
Mouse heart model with surgical constriction of the left coronary artery without reperfusion
I
Intervention
24-hour ischemia
C
Comparator
Control tissue
O
Outcome
Gene expression profile in heart RNA using a mouse cDNA array containing 588 known genessurrogate

Ischemic injury in the mouse heart induces a fetal transcription program and stress responses, which may be involved in post-ischemic remodeling.

Cite This Study

Lyn et al. (2000) studied this question.

synapsesocial.com/papers/6a7d64131e40f448689665f3https://doi.org/10.1152/physiolgenomics.2000.2.3.93
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Developmental regulation of myosin gene expression in mouse cardiac muscle.1990 · 420 citations
  2. 2Physiological assessment of complex cardiac phenotypes in genetically engineered mice1997 · 103 citations
  3. 3Electrical remodeling in ischemia and infarction1999 · 205 citations
  4. 4Molecular signalling mechanisms controlling growth and function of cardiac fibroblasts1995 · 230 citations