Key result
Alamandine significantly attenuated cardiac dysfunction and fibrosis induced by chronic hypertension in aged spontaneous hypertensive rats, independent of blood pressure reduction.
Why the study?
Few therapeutic agents treat hypertension-induced cardiac fibrosis, and whether the renin-angiotensin system heptapeptide alamandine protects against this condition was unknown.
Does alamandine improve cardiac fibrosis and dysfunction in a spontaneous hypertensive rat model?
Does alamandine improve cardiac fibrosis and dysfunction in a spontaneous hypertensive rat model?
p-value: p=<0.05
Alamandine is an effective anti-hypertensive peptide that attenuates cardiac dysfunction and fibrosis induced by chronic hypertension in rats, independent of blood pressure reduction.
No takes yet. Share an insight, caveat, or question.
Should not change clinical practice; extends preclinical evidence for alamandine in hypertensive fibrosis models.
Wang et al. (2019) studied Hypertension-induced cardiac fibrosis (n=24). Alamandine vs. Hydralazine (10 mg/kg/day) or saline was evaluated on Cardiac fibrosis density and fibrotic protein expression (p=<0.05). Alamandine significantly attenuated cardiac dysfunction and fibrosis induced by chronic hypertension in aged spontaneous hypertensive rats, independent of blood pressure reduction.
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