Key result
Transcatheter aortic valve implantation with the Lotus valve was associated with a higher rate of permanent pacemaker requirement at discharge compared to the Sapien XT valve (24.0% vs 6.7%, P=0.07).
Why the study?
Does the Lotus valve compared to the Edwards Sapien XT valve alter electrophysiological parameters and pacemaker requirement in patients undergoing TAVI?
Population
55 patients undergoing transcatheter aortic valve implantation (TAVI) due to severe aortic valve stenosis
Comparison
Boston Scientific Lotus prosthesis (n=25) vs Edwards Sapien XT prosthesis (n=30)
Design
Cohort
Follow-up
at discharge
Authors
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May favor Sapien XT to limit pacemaker risk; leaves open randomized confirmation of comparative safety.
Observational (n=55)
Does the Lotus valve compared to the Edwards Sapien XT valve alter electrophysiological parameters and pacemaker requirement in patients undergoing TAVI?
Absolute Event Rate: 24% vs 6.7%
p-value: p=0.07
The Lotus valve is associated with a greater impact on atrioventricular conduction systems and a trend toward higher pacemaker requirement compared to the Sapien XT valve, though it has less paravalvular leakage.
Eksik et al. (2016) conducted an observational in severe aortic valve stenosis (n=55). Boston Scientific Lotus valve vs. Edwards Sapien XT valve was evaluated on Permanent pacemaker requirement at discharge (p=0.07). Transcatheter aortic valve implantation with the Lotus valve was associated with a higher rate of permanent pacemaker requirement at discharge compared to the Sapien XT valve (24.0% vs 6.7%, P=0.07).
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