Key result
In patients with severe symptomatic aortic stenosis undergoing TAVI, the presence of coronary artery disease was associated with a 2.6-fold higher adjusted hazard of 2-year all-cause mortality.
Why the study?
Does the presence of coronary artery disease impact mortality in patients with severe symptomatic aortic stenosis undergoing TAVI?
Population
91 consecutive patients with severe symptomatic aortic stenosis undergoing TAVI, mean age 79 ± 9 years, 52%…
Comparison
Presence of coronary artery disease, with a… vs Absence of coronary artery disease (CAD)
Design
Cohort
Follow-up
median 16 months
Authors
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CAD signals higher long-term TAVI mortality risk; leaves open whether revascularization improves outcomes.
Observational (n=91)
No
Does the presence of coronary artery disease impact mortality in patients with severe symptomatic aortic stenosis undergoing TAVI?
Hazard Ratio: 2.6 (95% CI 1.1–6)
Absolute Event Rate: 50% vs 24%
p-value: p=0.03
The presence of coronary artery disease in patients undergoing TAVI is associated with significantly higher long-term mortality, although 30-day procedural outcomes are similar.
Mâncio et al. (2015) conducted an observational in Symptomatic severe aortic valve stenosis (n=91). Coronary artery disease (CAD) vs. No coronary artery disease was evaluated on 2-year all-cause mortality (adjusted HR 2.6, 95% CI 1.1-6.0, p=0.03). In patients with severe symptomatic aortic stenosis undergoing TAVI, the presence of coronary artery disease was associated with a 2.6-fold higher adjusted hazard of 2-year all-cause mortality.
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