Impact of coronary artery disease on outcomes of severe aortic stenosis treatment with transcatheter aortic valve implantation

Introduction: The presence of coronary artery disease (CAD) in patients who underwent transcatheter aortic valve implantation (TAVI) may increase in-hospital and long-term mortality.Aim: To evaluate the impact of CAD in patients who underwent TAVI. Material and methods:The study group consisted of the first 142 patients treated with TAVI between 26 November 2008 and 31 December 2015.The patients were divided into two groups: group I comprised 103 (72.5%) patients with CAD, and group II comprised 39 (27.5%) patients without CAD.Results: Group I was characterized by a significantly higher risk according to EuroSCORE -11.2 ±2.5 vs. 9 ±2.3 in group II (p < 0.001) and Logistic EuroSCORE -25.4 ±13.4 vs. 16.3 ±8.7 (p < 0.001).30-day mortality was 8 (7.8%) vs. 2 (5.1%) (p = NS) and 1-year mortality was 22 (21.4%) vs. 6 (15.4%) (p = NS) in group I and II respectively.The composite endpoint evaluating the efficacy of TAVI was achieved in 82 (79.6%) vs. 31 (79.5%)(p = NS) in group I and II respectively.The composite endpoint, which involved 30-day observation, occurred in 39 (37.86%) vs. 12 (30.77%)(p = NS) and the composite endpoint, which involved 1-year evaluation of the clinical efficacy of TAVI, occurred in 48 (57.8%) vs. 13 (48.1%)(p = NS) in patients with and without CAD respectively.Conclusions: The short-and mid-term outcomes of TAVI patients with CAD, despite higher risk profile, did not differ from the outcomes of treatment in patients without CAD.Key words: percutaneous coronary intervention, coronary artery disease, coronary artery bypass graft, transcatheter aortic valve implantation. S u m m a r yWe decided to submit the manuscript for your consideration since it concerns a very important clinical problem.This paper may be of significant importance since, to the best of our knowledge it is the first to present data concerning coronary artery disease (CAD) in patients treated with transcatheter aortic valve implantation (TAVI) based on the endpoints suggested by the VARC.The incidence of CAD was found not to affect the in-hospital and 1-year outcomes of treatment of patients suffering from AS using TAVI.