December 10, 2008Psychosomatic Medicine
Common Genetic Contributions to Depressive Symptoms and Inflammatory Markers in Middle-Aged Men: The Twins Heart Study
Population
188 male twins from the Vietnam Era Twin Registry who were free of symptomatic coronary artery disease and…
Design
Cross-sectional
Authors
Discussion
Loading...
Member takes
Implication
Shared genetic influences link IL-6 to depressive symptoms; hypothesis-generating and should not yet alter clinical practice.
Structured PICO
P
Population
188 male twins from the Vietnam Era Twin Registry who were free of symptomatic coronary artery disease and major depressive disorder, mean age 55 ± 2.75 years, including 54 monozygotic and 40 dizygotic twin pairs.
O
Outcome
Phenotypic association between current depressive symptoms (measured by Beck Depression Inventory-II) and inflammatory markers (IL-6 and CRP), and the genetic and environmental contributions to this association.surrogate
In middle-aged men without major depressive disorder, current depressive symptoms correlate with inflammatory markers, largely driven by shared genetic influences.
Cite This Study
Su et al. (2008) studied this question.