Key result
Higher serum troponin-I levels (≥ 0.4 ng/ml) were significantly associated with lower left ventricular ejection fraction (45.95% vs 56.30%) and a higher proportion of left ventricular systolic dysfunction following a first episode of NSTEMI.
Why the study?
The relationship between troponin-I levels and left ventricular systolic dysfunction following a first episode of NSTEMI had not yet been examined in the study population.
Does a higher serum troponin-I level associate with left ventricular systolic dysfunction in patients with a first episode of NSTEMI?
Cross-Sectional (n=160)
No
Does a higher serum troponin-I level associate with left ventricular systolic dysfunction in patients with a first episode of NSTEMI?
Absolute Event Rate: 45.95% vs 56.3%
p-value: p=<0.05
In patients with a first episode of NSTEMI, a serum troponin-I level ≥0.4 ng/ml is significantly associated with lower left ventricular ejection fraction and a higher incidence of systolic dysfunction.
Hypothesis-generating for troponin-I in NSTEMI risk stratification; prospective studies needed before clinical adoption.
Background: Serum troponin is an exquisitely sensitive marker of myocardial injury and is necessary for establishing the diagnosis of Myocardial Infarction particularly non-ST elevation myocardial infarction (NSTEMI). However, the relation of troponin-I level with left ventricular systolic dysfunction following first episode of NSTEMI are still not examined in our population. Therefore, to determine the relationship of serum troponin I with left ventricular ejection fraction after first episode of NSTEMI was set as an objective of the study. Methods: This cross sectional analytical study was conducted on 160 patients. They were divided into the two groups (80 patients in each group): Group-A (Troponin I level e” 0.4 ng/ml) high risk group and Group-B (Troponin I level < 0.4 ng/ml) low risk group. Left ventricular systolic dysfunction was defined as ejection fraction (EF%) < 50% calculated by modified Simpson’s method on transthoracic echocardiography. Association of troponin-I level with left ventricular systolic function was determined. Results: Among a total 160 patients, no significant variation across the group A and B in terms of age, gender and occupation (p>0.05 in all cases). Median serum troponin I of group A was 7.24 (range: 0.41- 58.25) and group B was 0.21(range: 0.12-0.39). Left ventricular EF was significantly lower in higher troponin I group (Group A-45.95±10.28 vs. Group B-56.30±7.78; p<0.05) and it was associated with higher proportion of left ventricular dysfunction (p<0.05). Conclusion: Serum troponin-I can be considered as a predictor of the left ventricular systolic dysfunction in first episode of Non-ST elevation myocardial infarction patients. Cardiovasc j 2022; 15(1): 42-48
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Islam et al. (2022) conducted a cross-sectional in First episode of Non-ST Elevation Myocardial Infarction (NSTEMI) (n=160). Serum Troponin-I level ≥ 0.4 ng/ml vs. Serum Troponin-I level < 0.4 ng/ml was evaluated on Left ventricular ejection fraction (LVEF) (p=<0.05). Higher serum troponin-I levels (≥ 0.4 ng/ml) were significantly associated with lower left ventricular ejection fraction (45.95% vs 56.30%) and a higher proportion of left ventricular systolic dysfunction following a first episode of NSTEMI.
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