Key result
Overexpression of angiotensinogen in white adipose tissue caused glucose intolerance and systemic insulin resistance in male mice, driven by reduced skeletal muscle glucose uptake and inflammation.
Why the study?
Does overexpression of angiotensinogen in white adipose tissue cause systemic insulin resistance and adipose inflammation in mice?
Population
Male mice overexpressing angiotensinogen (Agt) in white adipose tissue (aP2-Agt mice) and 3T3-L1 adipocytes
Comparison
Overexpression of angiotensinogen in white… vs Wild-type mice and untreated adipocytes
Design
Preclinical
Authors
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Adipose angiotensinogen overexpression may drive insulin resistance in mice; hypothesis-generating and leaves open human translation.
Does overexpression of angiotensinogen in white adipose tissue cause systemic insulin resistance and adipose inflammation in mice?
Overactivation of the adipose renin-angiotensin system directly causes glucose intolerance and systemic insulin resistance via increased adipose inflammation.
Kalupahana et al. (2011) studied Insulin resistance and glucose intolerance. Overexpression of angiotensinogen (Agt) in white adipose tissue vs. Wild-type/control genotype was evaluated on Glucose tolerance, systemic insulin sensitivity, and WAT inflammatory markers. Overexpression of angiotensinogen in white adipose tissue caused glucose intolerance and systemic insulin resistance in male mice, driven by reduced skeletal muscle glucose uptake and inflammation.
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