Key result
Constitutive activation of the renin-angiotensin system in mice resulted in lower epididymal fat mass and improved glucose tolerance without causing insulin resistance.
Why the study?
Does constitutive activation of the renin-angiotensin system alter glucose tolerance and energy balance in mice?
Does constitutive activation of the renin-angiotensin system alter glucose tolerance and energy balance in mice?
Chronic renin-angiotensin system activation in mice reduces visceral fat and improves glucose tolerance without causing insulin resistance.
Caution against clinical extrapolation; extends preclinical evidence on RAS modulation of adiposity and glucose handling.
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Favrè et al. (2014) studied Glucose homeostasis and energy balance. Constitutive RAS activation (dTGM model) and ramipril vs. Controls was evaluated on Energy balance, renal functions, glucose and insulin tolerance. Constitutive activation of the renin-angiotensin system in mice resulted in lower epididymal fat mass and improved glucose tolerance without causing insulin resistance.
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